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吴崇明
2024-10-10 10:55   审核人:

吴崇明,汉族,中共党员,理学博士,研究员,博士生导师。毕业于中国科威尼斯人app大学,博士学位,现任威尼斯人app药理教研室专任教师。

主要从事肠道微生物药物药理学研究。担任中国药理学会心血管药理专业委员会委员等。主讲《威尼斯人app》《威尼斯人app》等课程。主持国家自然科学基金3项。以第一作者或通讯作者发表论文88篇,其中SCI收录论文73篇、被引3000余次。

承担科研项目情况:

起止年份

课题名称

基金类别

2020-2023

精准肠道菌研究在菌株水平解析肠道菌群促进胰高血糖素样肽-1(GLP-1)分泌的功能及活性分子发现

国家自然基金(面上)

2017-2020

基于特征性肠道菌种及其功能基因和活性代谢产物探究小檗碱降血脂功效的肠道机制

国家自然基金(面上)

2018-2019

人类肠道菌群500种单一菌种的调血脂功效及作用机制研究

青年医学人才奖励项目

2015-2017

虫草素上调促脂肪褐化关键因子irisin表达的分子机制研究

国家自然基金(青年)

2012-2012

FSP27调节脂滴融合的分子机制研究

中国博士后基金

主要代表性成果:

1. Zou L, et al. Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity. Biomed Pharmacother. 2024;172:116302. (IF:7.5)(中国科威尼斯人app1区)(通讯作者)

2. Zhong S, et al, The gut microbiota‐aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol‐rich extracts from Sanghuangporus. iMeta 2024;e180. (IF:23.7)(国内高起点期刊)(通讯作者)

3. Xu W, et al. Therapeutic potential of dietary nutrients and medicinal foods against metabolic disorders: Targeting Akkermansia muciniphila. Food Frontiers 2024; 1-21. (5year-IF:10.0)(国内高起点期刊)(通讯作者)

4. Wang X, et al. Oral bacteriome and mycobiome of patients with idiopathic membranous nephropathy with different tongue coatings treated with a Chinese herbal formula. J Ethnopharmacol. 2024, In press. (IF:5.4)(中国科威尼斯人app1区)(通讯作者)

5. Xu W, et al. Strain-level screening of human gut microbes identifies Blautia producta as a new anti-hyperlipidemic probiotic. Gut Microbes. 2023;15(1):2228045. (IF:12.2)(中国科威尼斯人app1区)(通讯作者)

6. Yang Z, et al. Gut microbiota and hypertension: association, mechanisms and treatment. Clin Exp Hypertens. 2023;45(1):2195135. (IF:12.3)(通讯作者)(ESI高被引论文)

7. Dong C, et al. Gut microbiota combined with metabolites reveals unique features of acute myocardial infarction patients different from stable coronary artery disease. J Adv Res. 2023;46:101-112. (IF:12.8)(通讯作者)(ESI高被引论文)

8. Yang Y, et al. The linkage of gut microbiota and the property theory of traditional Chinese medicine (TCM): Cold-natured and sweet-flavored TCMs as an example. J Ethnopharmacol. 2023 Apr 24;306:116167. (IF:5.4)(中国科威尼斯人app1区)(通讯作者)

9. Yang Y, et al. Traditional Chinese medicines (TCMs) with varied meridians (Gui-Jing) differentially alleviate the adverse impact of Coptis chinensis on gut microbiota. J Ethnopharmacol. 2023 May 10;307:116256.   (IF:5.4)(中国科威尼斯人app1区)(通讯作者)

10. Wu C, et al. Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR's cholesterol-decreasing efficacy in patients. J Adv Res. 2022; 37:197–208. (IF:12.822)(中国科威尼斯人app1区)(通讯作者)(ESI高被引论文)

11.  Li C, et al. Deep insights into the gut microbial community of extreme longevity in south Chinese centenarians by ultra-deep metagenomics and large-scale culturomics. NPJ Biofilms Microbiomes. 2022 Apr 19;8(1):28.(5YEAR-IF:9.67)(中科院1区)(通讯作者)(Nature小子刊)

12.  Chen R, et al. Orally administered Bi2S3@SiO2 core-shell nanomaterials as gastrointestinal contrast agents and their influence on gut microbiota. Mater Today Bio. 2022;13:100178.(IF:10.761)(中国科威尼斯人app1区)(通讯作者)

13.  Wang X, et al. Structural modulation of gut microbiota during alleviation of experimental passive Heymann nephritis in rats by a traditional Chinese herbal formula. Biomed Pharmacother. 2022 Jan;145:112475.(IF:7.419)(中国科威尼斯人app1区)(通讯作者)

14. Duan Y, et al. Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health: A case-controlled study. Int J Clin Health Psychol. 2022;22(3):100323.(IF:5.9)(中国科威尼斯人app1区)(通讯作者)

15. Yang Y and Wu C. Targeting Gut Microbial Bile Salt Hydrolase (BSH) by Diet Supplements: New Insights into Dietary Modulation of Human Health. Food Funct. 2022;13(14):7409-7422. (IF:6.317)(中国科威尼斯人app1区)(通讯作者)

16. Yang Y, et al. Dual modulation of gut bacteria and fungi manifests the gut-based anti-hyperlipidemic effect of Coptidis Rhizoma. Biomed Pharmacother. 2022;153: 113542. (IF:7.419)(中国科威尼斯人app1区)(通讯作者)

17. Yang Y, et al. The berberine-enriched gut commensal Blautia producta ameliorates high-fat diet (HFD)-induced hyperlipidemia and stimulates liver LDLR expression. Biomed Pharmacother. 2022;155:113749. (IF:7.419)(中国科威尼斯人app1区)(通讯作者)

18. Li H, et al. Adenosine-rich extract of Ganoderma lucidum: a safe and effective lipid-lowering substance via regulating expression and modulation of PPAR signaling pathway. iScience. 2022 Sep 26;25(11):105214.(IF:6.107)(通讯作者)(Cell小子刊)

19. Yang Y, et al. The Gut Microbial Co-Abundance Gene Groups (CAGs) Differentially Respond to the Flavor (Yao-Wei) of Chinese Meteria Medica. Am J Chin Med. 2022, 50(7):1-22. (IF:6.005)(中国科威尼斯人app1区)(通讯作者)

20. Zhang Y, et al. Laurolitsine ameliorates type 2 diabetes by regulating the hepatic LKB1-AMPK pathway and gut microbiota. Phytomedicine. 2022 Nov;106:154423. (IF:6.656)(中国科威尼斯人app1区)(通讯作者)

21 Qiao J, et al. Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction. Nanoscale 2021. 13(19):8806-8816 (IF:7.79)(中国科威尼斯人app1区)(封面论文)(通讯作者)(ESI高被引论文)

22 Zhang X, et al. The Traditional Chinese Medicines differentially modulate the gut microbiota on the base of their natures (Yao-Xing). Phytomedicine 2021; 85:153496 (IF:6.66)(中国科威尼斯人app1区) (通讯作者)

23. Qi G, et al. Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway. Acta Pharm Sin B. 2019 Jan;9(1):135-143. (IF:6.014,中国科威尼斯人app1区) (通讯作者)

24. Wu C, et al. The pandanus tectorius fruit extract (PTF) modulates the gut microbiota and exerts anti-hyperlipidaemic effects. Phytomedicine. 2019;58: 152863. (IF:4.18,中国科威尼斯人app1区) (通讯作者)

25. Li Y, et al.  The mulberry-derived 1-deoxynojirimycin (DNJ) inhibits high-fat diet (HFD)-induced hypercholesteremia and modulates the gut microbiota in a gender-specific manner. J Funct Foods. 2019; 52: 63-72. (IF:3.47,中国科威尼斯人app1区)

26. Li J, et al. The Antihyperlipidemic Effects of Fullerenol Nanoparticles via Adjusting the Gut Microbiota in vivo. Part Fibre Toxicol 2018, 15(1):5. (5-year IF:9.628,中国科威尼斯人app1区) (通讯作者)

27. Li J, et al. Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure. Nanoscale. 2018;10(16):7736-7745. (IF:7.736,中国科威尼斯人app1区) (通讯作者)


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