杨珍,汉族,中共党员,医学博士,高级实验师,硕士生导师。毕业于北京中医药大学。
主要从事中药信息学、基于结局效应的中药药效特点发现及作用机制研究,担任中药系统科学与工程专业委员会委员、中华中医药学会中药分析分会青年委员、中国药理学会心血管药理专业委员会青年委员、中华中医药学会中药毒理学与安全性研究分会青年委员、威尼斯人app市药理学会网络药理学专业委员会委员。主讲《威尼斯人app》、《威尼斯人app》、《威尼斯人app》等课程。主持国家自然科学基金1项、省部级重点重大项目子课题1项、威尼斯人app市中医药重点领域科研项目1项、威尼斯人app市卫生健康委中医-中西医结合科研项目1项、威尼斯人app市教委科研计划项目1项、企业委托项目2项。以第一作者或通讯作者发表论文30篇,其中SCI收录论文20篇。参编国内外著作2部。作为主要发明人申请专利9项,获专利授权3项。荣获威尼斯人app市科技进步三等奖1项。
承担科研项目情况:
1. 国家自然科学基金,基于“动因-效应”定向关联的开心散“化痰益智”防治AD治则内涵的研究,主持
2. 威尼斯人app市中医药重点领域科研项目,知柏药对调控CaMKKβ-AMPK信号通路维持神经元线粒体稳态“清热解毒”防治AD的因果机制研究,主持
3. 威尼斯人app市卫生健康委中医、中西医结合科研项目,基于神经元线粒体稳态的开心散“化痰益智”防治AD的机制研究,主持
4. 威尼斯人app市教委科研计划项目,基于神经、免疫串扰AChE/JAK – STAT - NF-κB通路的伸筋草治疗RA的物质基础及作用特点研究,主持
5. 现代中医药海河实验室项目,糖尿病认知损伤脑单细胞转录图谱及滋肾方防治配伍机制研究,子课题三,主持
6. 国家重点研发计划,中药复方保健产品核心功效现代科学内涵示范研究,参与
主要代表性成果:
1. Yanhua Chen#, Huimin Liu#, Rui Han#, Jiayi Lin, Jingyi Yang, Maojuan Guo, Zhen Yang*, Lili Song*. Analyzing how SiMiao Wan regulates ferroptosis to prevent RA-ILD using metabolomics and cyberpharmacology [J]. Phytomedicine, 2024, 133: 155912.
2. Miao Zeng#, Yue Zhang#, Xiaolu Zhang, Wenlan Zhang, Qun Yu, Wenyun Zeng, Dongming Ma, Jiali Gan, Zhen Yang*, Xijuan Jiang*. Two birds with one stone: YQSSF regulates both proliferation and apoptosis of bone marrow cells to relieve chemotherapy-induced myelosuppression [J]. Journal of Ethnopharmacology, 2022, 289: 115028.
3. Zhen Yang#, Xinyuan Shi, Jiale Ren#, Hongqing Yin, Dongna Li, Lili Song*, Yanjun Zhang*. Mitochondrial homeostasis is involved in inhibiting hippocampus neuronal apoptosis during ZSWF ameliorate the cognitive dysfunction of SAMP8 mice [J]. Journal of functional foods, 2022, 91: 101010.
4. Zhen Yang#, Xin Zhang#, Jinxia Wei#, Hui Zhao, Xiujun Zhang, Pengwei Zhuang, Yubo Li*, Yanjun Zhang*. A novel strategy for the discovery and validation of allergic component and its action mechanism in Red Ginseng [J]. Journal of functional foods, 2021, 104813.
5. Shanshan Fan, Qingsheng Yin, Dongna Li, Jing Ma, Lili Li, Shiwei Chai, Hong Guo*, Zhen Yang*. Anti-neuroinflammatory effects of Eucommia ulmoides Oliv. In a Parkinson's mouse model through the regulation of p38/JNK-Fosl2 gene expression [J]. Journal of Ethnopharmacology, 2020, 260: 113016.
6. Xin Wu#, Xiujiang Han#, Lili Li, Simiao Fan, Pengwei Zhuang, Zhen Yang*, Yanjun Zhang*. iTRAQ-based quantitative proteomics and target-fishing strategies reveal molecular signatures on vasodilation of Compound Danshen Dripping Pills [J]. Chem Biol Interact, 2020, 316: 108923.
7. Zhen Yang, Qingsheng Yin, Jing Ma, Changshuo Yang, Yuanyuan Sheng, Lili Song, Tan Pang, Pengwei Zhuang, Hong Guo*, Yanjun Zhang*. Screen the Effective Components of Lycopodii herba on Rheumatoid Arthritis with the Aid of Spectrum-Effect Relationship and Uncover its Potential Mechanism [J]. Inflammation, 2020, 43(6): 2087-2097.
发明专利授权:
杨珍, 张艳军, 庄朋伟, 郭虹. 一种中药网络药理深度分析方法与系统[Z]. 2021-05-10, 中国, ZL202110094723.2
威尼斯人app:yzwygb@126.com